Welcome to the Human Tissue Resource Center. The mission of this CAP-accredited core facility is to provide investigators with a centralized infrastructure to optimize the efficiency and costs related to research involving biospecimens. The HTRC occupies 4000 square feet of remodeled space within Pathology and functions as an integrated unit. Thus, duplication of personnel, equipment, and information systems are avoided, and coordination of activities is assured.

    The HTRC now comprises four integrated facilities: Biospecimen Bank (BSB), Laser Capture Microdissection (LCM), Digital Pathology and Histology (including immunohistochemistry).

    Currently the HTRC provides services for the collection of clinically-annotated human tissues, DNA, PBMC, saliva, and other requested body fluids. In addition, the core also provides services for tissue microarray (TMA) construction as well as cryostats and digital imaging for investigators use. In this way, the HTRC provides a coordinated, centralized, and dedicated program for the procuring, processing, dispersing and assessing all types of biospecimens together with downstream histology services.


    Technology Update: RNA In Situ Hybridization

    Up to 4 RNA probes can be visualized using the Leica Bond RX autostainer. This image is of a formalin fixed paraffin embedded xenograft section stained with the RNAscope LS multiplex fluorescent kit from ACD with the Opal 7-color FIHC kit from PerkinElmer. Four fluorescent RNA probes plus a blue nuclear counterstain are shown. To learn more about using this technique, email Terri Li.

    Acknowledgement of core facility contributions in publications is appreciated.

    Cancer Center members should cite the Cancer Center Support Grant (P30CA014599) when publishing any work assisted by this core facility.